The game takes place after the events of Wings of Liberty, where Raynor's Raiders have launched a campaign to take down the Zerg Swarm's leader, Abathur. However, a new threat emerges in the form of the Zerg Overmind's former pawn, Dehaka, who seeks to take control of the Swarm. Players join Raynor on a perilous journey to unite the fragmented rebel groups and take down Dehaka and his minions.