Mujhse Dosti Karoge revolves around the lives of two childhood friends, Sanju (played by Manan Bhogal) and Pooja (played by Sara Ali Khan). The story takes off from a nostalgic note, showcasing their beautiful bond as kids, which gradually drifts apart as they grow older. The movie then fast-forwards to their reunion, where they reconnect and discover that their friendship has transformed into something more.